Melanin has a high affinity with DNA pheomelanin Pigment found in relatively high quantities in individuals withĬonversely, in the absence of cysteine, dopaquinone isĬonverted into dopachrome, which results in the formation ofĮumelanin, an alkaline, brownish pigment that is able to absorbĪnd disperse UV radiation, thus reducing the harmful effects of The final product will be pheomelanin, an alkaline, yellowish In the presence of cysteine (glutathione), Nase oxidizes tyrosine and transforms it into DOPA, and then Tyrosine, an essential amino acid, is the starting element The sun have a density of melanocytes up to twice that of non. Whereas in dark skin, they are larger and dispersed individually,Īnd degrade slowly (thus allowing melanin granules to be found Melanosomes and the degree of enzymatic activity involved inįound in clusters, and degrade in the middle malpighian layer, The melanocytes'''''''' activity can be influenced by the size of the Radiation, which directly stimulate the production of melanin Pheomelanin and eumelanin, and external factors such as UV Quality of the melanosomes, the proportion and distribution of Pigmentation are due to the melanocytes'''''''' degree of activity, the The racial phenotypic differences related to cutaneous Nations of depigmenting agents to manage melasma. Menting agent, it causes many adverse effectsĮncourages the development of new products and new combi. Although hydroquinone is the most widely used depig. Ters, lasers, intense pulsed light, chemical peels, and dermabra. It is worth noting that quality of life can improve with treat-Īmong the therapeutic options are: topical depigmen. Which can be evaluated with the MELASQoL questionnaire Women and is very resistant to treatment,ĭerable number of studies on its treatmentĬan negatively affect patients'''''''' social and emotional balance, Melasma is a melanodermia that primarily affects
Volunteers with excellent/good tolerance of the product than (p <0.001), given that Group C had a smaller percentage of Between groups A and CĪnd between Groups B and C, there were statistical differences There were no statistical differences in those items between Group B had 19 (58%) excellent ratings, 13 (39%) good, In the item tolerability on D90, Group A had 16 (47%)Įxcellent ratings, 16 (47%) good, 2 (6%) regular, and zero bad
The Melasma Area Severity Index metrics presented a statistically significant decrease (i.e., improvement) throughout the study in all three groups (p-value Results: Most volunteers (n = 102, 85%) completed the study (Group A = 34, Group B = 33, Group C = 35). Clinical (classification and quantification of melasma) and photographic evaluations were carried out, and a questionnaireĪssessed the impact on the patients'''''''' quality of life and the products'''''''' general efficacy. The study population was divided into 3 groups: Group A (n = 40 Blancy®, 2 times a day), Group B (n = 40, 2% hydroquinone at night), and Group C (n = 40, 4% hydroquinone at night), and instructed to use the study product for 90 consecutive days.
Methods: A single-blind, comparative, monocentric clinical study with 120 volunteers (aged 18-50, I to IV Fitzpatrick skin types) was conducted. Objectives: To evaluate the efficacy, safety, and tolerability of the topical combination of kojic acid, arbutin, sepiwhite® and achromaxyl ® compared to 2% and 4% hydroquinone Janeiro/RJ – Brazil provided the material usedĪbstract Introduction: Melasma is a common, acquired, long-lasting skin disorder that is often resistant to treatment and causes negative psychological effects on patients.